Clinical studies and
scientific research
Here you’ll find several scientific studies demonstrating the effectiveness of Vitamin A (including retinol and related retinoids) in addressing skin aging and skin renewal. These studies primarily focus on improvements in wrinkles, skin texture, and moisture levels:
Kafi R, Kwak HS, Schumacher WE, Cho S, Hanft VN, Kang S, Fisher GJ, Voorhees JJ, Varani J. (2007). Improvement of Naturally Aged Skin with Vitamin A (Retinol). Archives of Dermatology, 143(5), 606-12.
Result: Topical retinol led to a significant improvement in fine lines and increased collagen production in naturally aged skin.
Varani J, Fisher GJ, Kang S, Voorhees JJ. (2016). Molecular mechanisms of intrinsic skin aging and retinoid therapy. Dermatologic Therapy, 29(5), 364–375.
Result: Shows the molecular mechanisms by which retinoids (including retinol) promote collagen synthesis while inhibiting collagen breakdown.
Kang S, Leyden JJ, Lowe NJ, Matts PJ, Kollias N, Larnier C, et al. (2001). Photodamage and Topical Retinoic Acid Therapy. Journal of the European Academy of Dermatology and Venereology, 15(Suppl 3), 28-33.
Result: Retinoic acid (the active form of Vitamin A) improves signs of photoaging such as wrinkles and hyperpigmentation.
Kim J, Kim S, Shin HS, Kim J, Jung E, et al. (2013). Efficacy of Retinyl Retinoate in the Improvement of Photoaged Skin. Dermatologic Therapy, 26(4), 267-271.
Result: Retinyl retinoate (a gentler form of retinol) causes less skin irritation while still effectively improving fine lines and skin texture.
Griffiths CEM, Kang S, Ellis CN, et al. (1995). Two concentrations of topical retinoic acid cause similar improvement of photodamage. Journal of the American Academy of Dermatology, 33(3), 384-390.
Result: Even at different concentrations, retinoic acid showed comparable improvements in wrinkles and skin texture.
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